• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 726 Citations
  • 15 h-Index
19962017

Research output per year

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Research Output

  • 726 Citations
  • 15 h-Index
  • 40 Article
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Article
2017

A preclinical screen to evaluate pharmacotherapies for the treatment of agitation in dementia

O’Hare, E., Page, D., Curran, W., Hong, J-S. & Kim, E-M., 1 Apr 2017, In : Behavioural Pharmacology. 28, 2 & 3, p. 199-206 8 p.

Research output: Contribution to journalArticle

Open Access
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3 Downloads (Pure)
2016

Lack of support for bexarotene as a treatment for Alzheimer's disease

O'Hare, E., Jeggo, R., Kim, E-M., Barbour, B., Walczak, J-S., Palmer, P., Lyons, T., Page, D., Hanna, D., Meara, J. R., Spanswick, D., Guo, J-P., McGeer, E. G., McGeer, P. L. & Hobson, P., 31 Jan 2016, In : Neuropharmacology. 100, p. 124-130 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2015

Effects of thyroxine treatment on histology and behavior using the methimazole model of congenital hypothyroidism in the rat

O’Hare, E., Kim, E-M., Page, D. & Reid, R., 2015, In : Neuroscience. 285, p. 128

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice

Rammes, G., Gravius, A., Ruitenberg, M., Wegener, N., Chambon, C., Sroka-Saidi, K., Jeggo, R., Staniaszek, L., Spanswick, D., O'Hare, E., Palmer, P., Kim, E-M., Bywalez, W., Egger, V. & Parsons, C. G., 2015, In : Neuropharmacology. 92, p. 170

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
2014

Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease

O'Hare, E., Scopes, D. I. C., Kim, E-M., Palmer, P., Spanswick, D., McMahon, B., Amijee, H., Nerou, E., Treherne, J. M. & Jeggo, R., 1 Jan 2014, In : The International Journal of Neuropsychopharmacology. 17, 01, p. 117-126 9 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
2013

AßPP over-expressing transgenic rat model of Alzheimer's disease utilizing the Tg2576 mouse protocol

O'Hare, E., Ardis, T., Page, D., Scopes, DI. & Kim, E-M., 2013, In : Journal of Alzheimer's Disease. 37, p. 77-88

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Effect of intracerebroventricular injection of Ti-02 nanoparticles on complex behavior in the rat

Kim, E-M., Palmer, P., Howard, V., Elsaesser, A., Taylor, A. & Staats, G., 2013, In : Journal of Nanoscience and Nanotechnology. 13, p. 1-6

Research output: Contribution to journalArticle

Novel 5-aryloxypirmidine SEN1576 as a candidate for treatment of Alzheimer's disease

O'Hare, E., Kim, E-M., Palmer, P., Scopes, DIC., Spanswick, D., McMahon, B., Treherne, JM. & Jeggo, R., 2013, In : International Journal of Neuropsychopharmacology. 0

Research output: Contribution to journalArticle

Orally bioavailable small molecule drug protects memory in Alzheimer's disease models

O'Hare, E., Scopes, D. I. C., Kim, E-M., Palmer, P., Jones, M., Whyment, A. D., Spanswick, D., Amijee, H., Nerou, E., McMahon, B., Treherne, J. M. & Jeggo, R., 2013, In : Neurobiology of Aging. 34, 4, p. 1116

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
2012

Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity

Scopes, DIC., O'Hare, E., Jeggo, R., Whyment, AD., Spanswick, D., Kim, E-M., Gannon, J., Amijee, H. & Treherne, JM., 2012, In : British Journal of Pharmacology. 167, 2, p. 383

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Effects of butorphanol on feeding and neuropeptide Y in the rat

Mitra, A., Kotz, C. M., Kim, E-M., Grace, M. K., Kuskowski, M. A., Billington, C. J. & Levine, A. S., 2012, In : Pharmacology Biochemistry and Behavior . 100, 3, p. 575

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2011

Novel anti-inflammatory compound SEN1176 alleviates behavioural deficits induced bilateral intrahippocampal injection of aggregated Ab1-42

O'Hare, E., Scopes, DIC., Treherne, JM., Monaghan, J., Palmer, PM., Amijee, H. & Kim, E-M., 2011, In : Journal of Alzheimer's Disease. 25, 2, p. 219-229

Research output: Contribution to journalArticle

18 Citations (Scopus)
2010

Behavioural deterioration induced by intrahippocampal NAC 61-95 injections and attenuation with ibuprofen

O'Hare, E., Elliott, J. J., Hobson, P., Spanswick, D. & Kim, E-M., 2010, In : Behavioural Brain Research. 208, p. 274-277

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Bilateral intrahippocampal NAC 61-95 effects on behavior and moderation with L-name treatment

O'Hare, E., Elliott, J. J., Hobson, P., O'Mara, S. M., Spanswick, D. & Kim, E-M., 2010, In : Neuroscience Research. 66, p. 213-218

Research output: Contribution to journalArticle

Open Access

Quantification of nanoparticle uptake by cells using microscopical and analytical techniques

Elsaesser, A., Taylor, A., Staats, G., McKerr, G., Kim, E-M., O’Hare, E. & Howard, V., 2010, In : NANOMEDICINE. 5, 9, p. 1447-1457

Research output: Contribution to journalArticle

Open Access
65 Citations (Scopus)

RS-0406 arrests amyloid-b oligomer-induced behavioural deterioration in vivo

O'Hare, E., Scopes, D. I. C., Treherne, M. J., Norwood, K., Spanswick, D. & Kim, E-M., 2010, In : Behavioural Brain Research. 210, p. 32-37

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)
2009

Effects of intrahippocampal NAC(61-95) injections on memory in the rat and attenuation with vitamin E

Kim, E-M., Elliot, J. J., Hobson, P. & O'Hare, E., Aug 2009, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 33, 6, p. 945-951

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Feeding association between the nucleus of the solitary tract and the ventral tegmental area

Kim, E-M., Quinn, J., Spanswick, D. & O'Hare, E., 2009, In : Appetite. 53, p. 457-460

Research output: Contribution to journalArticle

10 Citations (Scopus)
2008

Oligomers of the amyloid-beta protein disrupt working memory: Confirmation with two behavioral procedures

Poling, A., Morgan-Paisley, K., Panos, J. J., Kim, E-M., O'Hare, E., Cleary, J. P., Lesne, S., Ashe, K. H., Porritt, M. & Baker, L. E., Nov 2008, In : Behavioural Brain Research. 193, 2, p. 230-234

Research output: Contribution to journalArticle

Open Access
65 Citations (Scopus)
2007

Thyroxine replacement in an animal model of congenital hypothyroidism

Reid, R. E., Kim, E-M., Page, D., O'Mara, S. M. & O'Hare, E., Jun 2007, In : PHYSIOLOGY & BEHAVIOR. 91, 2-3, p. 299-303

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)
2006

An operant determination of the behavioral mechanism of benzodiazepine enhancement of food intake

O'Hare, E., Kim, E-M. & Tierney, K. J., Aug 2006, In : Psychopharmacology. 187, 2, p. 138-142

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Heterozygous Tg plus APP-overexpressing rats exhibit a behavioural deficit and ad-like pathology at nineteen months old

O'Hare, E., Ardis, T. C. & Kim, E-M., Sep 2006, In : Behavioural Pharmacology. 17, 5-6, p. 551

Research output: Contribution to journalArticle

2005

Chronic intracerebroventricular infusion of lipopolysaccharide: effects of ibuprofen treatment and behavioural and histopathological correlates

Richardson, RL., Kim, E-M., Gardiner, T. & O'Hare, E., Nov 2005, In : Behavioural Pharmacology. 16, 7, p. 531-541

Research output: Contribution to journalArticle

20 Citations (Scopus)

Granisetron attenuates exercise-induced conditioned taste aversion in the rat

Eccles, S., Kim, E-M. & O'Hare, E., Jun 2005, In : Appetite. 44, 3, p. 325-328

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated A beta((1-42)) injections

McDaid, DG., Kim, E-M., Reid, RE., Leslie, J., Cleary, J. & O'Hare, E., Jul 2005, In : Behavioural Pharmacology. 16, 4, p. 237-242

Research output: Contribution to journalArticle

2004

A bi-directional u-opioid-opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat

Kim, E-M., Quinn, JG., Levine, AS. & O'Hare, E., 2004, In : Brain Research. 1029, p. 135-139

Research output: Contribution to journalArticle

Behavioral and neurochemical mechanisms of the action of mild stress in the enhancement of feeding

O'Hare, E., Shaw, D., Tierney, KJ., Kim, E-M., Levine, AS. & Shephard, RA., Feb 2004, In : Behavioral Neuroscience. 118, 1, p. 173-177

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2003

Evidence for a mu-opioid-oploid connection between the paraventricular nucleus and ventral tegmental area in the rat

Quinn, JG., O'Hare, E., Levine, AS. & Kim, E-M., Nov 2003, In : Brain Research. 991, 1-2, p. 206-211

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)
2002

Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated A beta((1-42)) injections in the rat

Richardson, RL., Kim, E-M., Shephard, RA., Gardiner, T., Cleary, J. & O'Hare, E., Nov 2002, In : Brain Research. 954, 1, p. 1-10

Research output: Contribution to journalArticle

Effects of A beta oligimers and A beta plaques on learning and memory in the rat

O'Hare, E., Ardis, T., Page, D., Courtney, M., Shephard, R., Leslie, J., Kim, E-M., Cleary, J. & Richardson, L., Jul 2002, In : Neurobiology of Aging. 23, 1, Sup, p. 1451

Research output: Contribution to journalArticle

Injection of alpha-MSH, but not beta-endorphin, into the PVN decreases POMC gene expression in the ARC

Kim, E-M., Grace, MK., O'Hare, E., Billington, CJ. & Levine, AS., Mar 2002, In : NeuroReport. 13, 4, p. 497-500

Research output: Contribution to journalArticle

2001

Identification of central sites involved in butorphanol-induced feeding in rats

Kim, E-M., Shi, Q., Olszewski, PK., Grace, MK., O'Hare, E., Billington, CJ. & Levine, AS., Jul 2001, In : Brain Research. 907, 1-2, p. 125-129

Research output: Contribution to journalArticle

20 Citations (Scopus)
2000

ARC POMC mRNA and PVN alpha-MSH are lower in obese relative to lean Zucker rats

Kim, E-M., O'Hare, E., Grace, MK., Welch, CC., Billington, CJ. & Levine, AS., Apr 2000, In : Brain Research. 862, 1-2, p. 11-16

Research output: Contribution to journalArticle

1999

STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats

Kim, E-M., Grace, MK., Welch, CC., Billington, CJ. & Levine, AS., 1999, In : AJP - Regulatory, Integrative and Comparative Physiology. 276, p. 1320-1326

Research output: Contribution to journalArticle

76 Citations (Scopus)
1998

Effect of peripheral 2-DG on opioids and neuropeptide Y gene expression

Kim, E-M., Giraudo, SQ., Grace, MK., Billington, CJ. & Levine, AS., 1998, In : Brain Research. 792, p. 136-140

Research output: Contribution to journalArticle

18 Citations (Scopus)

Effects of palatability-induced hyperphagia and food restriction on mRNA levels of neuropeptide-Y in the arcuate nucleus

Kim, E-M., Welch, CC., Grace, MK., Billington, CJ. & Levine, AS., 1998, In : Brain Research. 806, p. 117-121

Research output: Contribution to journalArticle

36 Citations (Scopus)
1997

Lactation decreases mRNA levels of opiod peptides in the arcuate nucleus of the rat

Kim, E-M., Kotz, CM., Welch, CC., Grace, MK., Billington, CJ. & Levine, AS., 1997, In : Brain Research. 769, p. 303-308

Research output: Contribution to journalArticle

1996

Chronic food restriction and acute food deprivation decrease mRNA levels of opioid peptides in arcuate nucleus

Kim, E-M., Welch, CC., Grace, MK., Billington, CJ. & Levine, AS., 1996, In : American Journal of Physiology - Regulatory, Integratice and Comparateive Physiology. 270, p. 1019-1024

Research output: Contribution to journalArticle

86 Citations (Scopus)

Palatability-induced hyperphagia increases hypothalamic dynorphin peptide and mRNA levels

Kim, E-M., Welch, CC., Grace, MK., Billington, CJ. & Levine, AS., 1996, In : Brain Research. 721, p. 126-131

Research output: Contribution to journalArticle

122 Citations (Scopus)