Personal profile
Biography
Diane Lees-Murdock graduated from Ulster University with BSc Hons Biology (1st Class). She also completed her PhD at Ulster in Molecular Toxicology where she is currently Professor of Genomic Medicine. Diane is Lead for the Centre for Genomic Medicine where her research is focused on genomic and epigenomic regulation in normal development and disease with a particular focus on cardiovascular disease.
Diane has vast experience of conducting genetic and epigenetic studies, in cellular and animal models as well as human studies. She has a particular interest in nutriepigenomics, investigating the role of one-carbon metabolism in ensuring the faithful transmission of DNA methylation and how genetic variants in this important metabolic pathway play a role in aberrant methylation in hypertension to provide a greater insight into how nutrition influences the epigenome and cardiovascular risk.
To date Diane has published more than 30 scientific papers in top-ranked journals across several disciplines. She has attracted significant external funding from government agencies in UK and Ireland, charities and industry. Diane was Chair of the Royal Society of Biology NI Branch (2017-19) and has over 20 years of teaching experience at undergraduate and postgraduate level. She founded the PgDip Stem Cell Biology, was BSc Hons Biology Course Director (2014-2020) and lead Bio & Healthcare Sciences at Ulster as Academic Division Head (2020-24).
External positions
NI Chest Heart & Stroke Scientific Research Committee, NI Chest Heart & Stroke Association
2023 → …
Vital Visionary Estee Lauder Fellow
2021 → 2022
HSC Doctoral Fellowship Evaluation Panel, HSC Research and Development
2019 → 2022
Chairperson, Royal Society of Biology NI Branch
2017 → 2019
Genomics Partnership NI
Keywords
- Q Science (General)
- Epigenetics
- Nutrition
- nutriepigenomics
- cardiovascular disease
- hypertension
- methylation
- Genomics
- epigenomics
- epigenetic age
- one-carbon metabolism
- riboflavin
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 5 Gender Equality
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Collaborations and top research areas from the last five years
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Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype
Amenyah, S., McMahon, A., Ward, M., Deane, J., McNulty, H., Hughes, C., Strain, J. J., Horigan, G., Purvis, J., Walsh, C. & Lees Murdock, D., 1 Jun 2020, In: Biochimie. 173, p. 17-26 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Link opens in a new tab Citations (Scopus)487 Downloads (Pure) -
DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism
Amenyah, S., Ward, M., McMahon, A., Deane, J., McNulty, H., Hughes, C., Strain, J. J., Horigan, G., Purvis, J., Walsh, C. & Lees Murdock, D., 1 Jan 2021, In: International Journal of Cardiology. 322, p. 233-239 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Link opens in a new tab Citations (Scopus)170 Downloads (Pure) -
Influence of Nutrients involved in One-Carbon Metabolism on DNA Methylation in Adults: A Systematic Review and Meta-Analysis
Amenyah, S., Hughes, C., Ward, M., Roxborough, S., Deane, J., Thursby, S.-J., Walsh, C., Kok, D., Strain, S., McNulty, H. & Lees Murdock, D., 31 Aug 2020, In: Nutrition Reviews. 78, 8, p. 647-666 20 p., nuz094.Research output: Contribution to journal › Review article › peer-review
Open AccessFile44 Link opens in a new tab Citations (Scopus)247 Downloads (Pure) -
Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring trial)
McNulty, H., Rollins, M., Cassidy, T., Caffrey, A., Marshall, B., Dornan, J., McLaughlin, M., McNulty, B. A., Ward, M., Strain, J. J., Molloy, A. M., Lees Murdock, D. J., Walsh, C. P. & Pentieva, K., 31 Oct 2019, (Published online) In: BMC Medicine. 17, 1, p. 1-11 11 p., 196.Research output: Contribution to journal › Article › peer-review
Open AccessFile78 Link opens in a new tab Citations (Scopus)416 Downloads (Pure) -
Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial
Caffrey, A., Irwin, R. E., McNulty, H., Strain, J., Lees Murdock, D., McNulty, B., Ward, M., Walsh, C. & Pentieva, K., 9 Apr 2018, In: American Journal of Clinical Nutrition. 107, 4, p. 566-575 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile99 Link opens in a new tab Citations (Scopus)260 Downloads (Pure)
Activities
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National Conference in Regenerative Medicine: Exploring North/South Collaborations towards Joint Funding Opportunities
Lees-Murdock, D. (Organiser & Speaker) & Murphy, M. (Organiser)
7 Sept 2017Activity: Participating in or organising an event › Organising a conference, workshop, ...
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Queens University Belfast
Lees-Murdock, D. (Visiting lecturer)
2010 → 2011Activity: Visiting an external institution › Visiting an external academic institution
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Annual Lecture Royal Society of Biology
Lees-Murdock, D. (Keynote speaker)
2016Activity: Talk or presentation › Invited talk
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Chair Undergraduate Global Awards
Lees-Murdock, D. (Chair)
2015Activity: Participating in or organising an event › Organising a conference, workshop, ...
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NI Science Festival 2024: Genomic Healthcare in Practice
Lees-Murdock, D. (Organiser), Irwin, R. (Participant), Stafford, C. (Participant) & O'Neill, L. (Participant)
Feb 2024Activity: Participating in or organising an event › Organising a conference, workshop, ...
Press/Media
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Minister hails pioneering Ulster University research in Genomic Medicine
Lees-Murdock, D., Gault, V. & Irwin, R.
28/03/24
1 item of Media coverage
Press/Media: Research
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NI Chest, Heart & Stroke Research & Impact Statement 2024
1/03/24
1 Media contribution
Press/Media: Research
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Webinar "Our Genes & Blood Pressure"
Lees-Murdock, D., Ward, M. & Murphy, M.
27/03/23
1 Media contribution
Press/Media: Research
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Nutrition Reviews Podcast: Conversations with the author
Lees-Murdock, D. & Amenyah, S.
5/08/20
1 Media contribution
Press/Media: Research
Profiles
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Co-Centre for Sustainable Food Systems
Ward, M. (PI), Moore, A. (CoI), Logue, C. (CoI), Hughes, C. (CoI), Gill, C. (CoI), Lees-Murdock, D. (CoI), McSorley, E. (CoI), Simmons, G. (CoI), McNulty, H. (CoI), Pourshahidi, K. (CoI), Hoey, L. (CoI), Hollywood, L. E. (CoI), Allsopp, P. (CoI) & Price, R. (CoI)
Department of Agriculture, Environment & Rural Affairs (DAERA) of Northern Ireland (UK)
1/01/24 → 31/12/29
Project: Research
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Digital Health and Personalised Medicine: A Global Collaboration Initiative for Capacity Building across Malaysia, Indonesia, and Pakistan.
Elnaem, M. (PI), Courtenay, A. (CoI), Abuelhana, A. (CoI), Lees-Murdock, D. (CoI) & Singh, M. (CoI)
1/09/24 → 31/03/25
Project: Research
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Epigenetic effects of MTHFR genotype and riboflavin in hypertension using isogenic induced pluripotent stem cells
Lees-Murdock, D. (PI) & Ward, M. (CoI)
1/09/22 → 1/03/25
Project: Research
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Role of riboflavinin epigenetic modulation of hypertension
Lees-Murdock, D. (PI), Hughes, C. (CoI), Ward, M. (CoI) & Irwin, R. (CoI)
Northern Ireland Chest Heart and Stroke
1/05/22 → 1/03/24
Project: Research
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EpiRiboSH: Epigenetic effects of riboflavin supplementation in a randomised control trial of hypertensive patients stratified by MTHFR genotype
Lees-Murdock, D. (PI) & Ward, M. (CoI)
2/03/17 → 28/02/20
Project: Research