Research output per year
Research output per year
Personal profile
Biography
My research interests lie in investigating epigenetic regulation in normal development and disease e.g. osteoarthritis and hypertension.
We have a particular focus on the role of DNA methyltransferase enzymes in carrying out faithful transmission of the DNA methylation pattern and their contribution to onset and pathology of disease.
Additionally we are also investigating the influence of environmental factors such as nutrients and xenobiotics on DNA methylation maintenance and reprogramming.
Teaching interests
Diane obtained a Postgraduate Certificate in Higher Education Practice and has been a Fellow of the Higher Education Authority since 2008.She designed and leads the innovative online Postgraduate Diploma Stem Cell Biology programme which was developed with BBSRC Modular Training for Industry funding. For full details of this course see our prospectus page.
Administrative roles
Chairperson for the Royal Society of Biology (2017-2019), N. Ireland Branch
Chair of the judging panel of the Undergraduate Awards Life Sciences section
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Chairperson, Royal Society of Biology NI Branch
2017 → 2019
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Can Nutritional Epigenomics Explain Persistent Effects of Periconceptional Folic Acid in the Methylome?
Lees-Murdock, D. & Ward, M., 26 Oct 2022, (Published online) In: The Journal of nutrition.Research output: Contribution to journal › Article › peer-review
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Evaluation of site-specific methylation of the CMV promoter and its role in CHO cell productivity of a recombinant monoclonal antibody
Dahodwala, H., Amenyah, S. D., Nicoletti, S., Henry, M., Lees-Murdock, D. J. & Sharfstein, S. T., 6 May 2022, (Published online) In: Antibody Therapeutics. 5, 2, p. 121-129 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)18 Downloads (Pure) -
Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms
Ondičová, M., Irwin, R. E., Thursby, S-J., Hilman, L., Caffrey, A., Cassidy, T., McLaughlin, M., Lees-Murdock, D. J., Ward, M., Murphy, M., Lamers, Y., Pentieva, K., McNulty, H. & Walsh, C. P., 16 May 2022, (Published online) In: Clinical Epigenetics. 14, 1, 20 p., 63 (2022).Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)9 Downloads (Pure) -
DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism
Amenyah, S., Ward, M., McMahon, A., Deane, J., McNulty, H., Hughes, C., Strain, J. J., Horigan, G., Purvis, J., Walsh, CP. & Lees Murdock, D., 1 Jan 2021, In: International Journal of Cardiology. 322, p. 233-239 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)43 Downloads (Pure) -
Effects of maternal folic acid supplementation during the second and third trimesters of pregnancy on neurocognitive development in the child: an 11-year follow-up from a randomised controlled trial
Caffrey, A., McNulty, H., Rollins, M., Prasad, G., Gaur, P., Talcott, J., Witton, C., Cassidy, T., Marshall, B., Dornan, J., Moore, AJ., Ward, M., Strain, JJ., Molloy, A., McLaughlin, M., Lees Murdock, D., Walsh, CP. & Pentieva, K., 10 Mar 2021, (Published online) In: BMC Medicine. 19, 1, 13 p., 73.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)76 Downloads (Pure)