Research Output per year
Personal profile
Biography
My research interests lie in investigating epigenetic regulation in normal development and disease e.g. osteoarthritis and hypertension.
We have a particular focus on the role of DNA methyltransferase enzymes in carrying out faithful transmission of the DNA methylation pattern and their contribution to onset and pathology of disease.
Additionally we are also investigating the influence of environmental factors such as nutrients and xenobiotics on DNA methylation maintenance and reprogramming.
Teaching interests
Diane obtained a Postgraduate Certificate in Higher Education Practice and has been a Fellow of the Higher Education Authority since 2008.She designed and leads the innovative online Postgraduate Diploma Stem Cell Biology programme which was developed with BBSRC Modular Training for Industry funding. For full details of this course see our prospectus page.
Administrative roles
Chairperson for the Royal Society of Biology (2017-2019), N. Ireland Branch
Chair of the judging panel of the Undergraduate Awards Life Sciences section
External positions
Chairperson
2017 → 2019Fingerprint Dive into the research topics where Diane Lees Murdock is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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DNA Methylation
Medicine & Life Sciences
Methylation
Medicine & Life Sciences
Folic Acid
Medicine & Life Sciences
Methyltransferases
Medicine & Life Sciences
Germ Cells
Medicine & Life Sciences
Randomized Controlled Trials
Medicine & Life Sciences
DNA
Medicine & Life Sciences
Pregnancy
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2003 2019
A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57.
Irwin, R. E., Thursby, S-J., Ondicova, M., Pentieva, K., McNulty, H., Richmond, R., Caffrey, A., Lees Murdock, D., McLaughlin, M., CASSIDY, T., Sudderman, M., Relton, C. & Walsh, CP., 18 Feb 2019, 11, 1, 16 p., 31.Research output: Contribution to journal › Article
Open Access
File
Folic Acid
Methylation
Randomized Controlled Trials
Pregnancy
Genetic Promoter Regions
Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring trial)
McNulty, H., Rollins, M., Cassidy, T., Caffrey, A., Marshall, B., Dornan, J., McLaughlin, M., McNulty, B. A., Ward, M., Strain, S., Molloy, A. M., Lees Murdock, D. J., Walsh, C. P. & Pentieva, K., 31 Oct 2019, In : BMC Medicine. 17, 1, p. 1-11 11 p., 196.Research output: Contribution to journal › Article
Open Access
File
Third Pregnancy Trimester
Second Pregnancy Trimester
First Pregnancy Trimester
Folic Acid
Randomized Controlled Trials
Influence of Nutrients involved in One-Carbon Metabolism on DNA Methylation in Adults: A Systematic Review and Meta-Analysis
Amenyah, S., Hughes, C., Ward, M., Roxborough, S., Deane, J., Thursby, S-J., Walsh, CP., Kok, D., Strain, S., McNulty, H. & Lees Murdock, D., 23 Dec 2019, In : Nutrition Reviews.Research output: Contribution to journal › Article
DNA Methylation
Meta-Analysis
Carbon
Food
Folic Acid
Folic Acid Supplementation throughout pregnancy: psychological developmental benefits for children
Henry, L-A., Cassidy, T., Cooper, M., Pentieva, K., McNulty, H., Walsh, C. & Lees Murdock, D., 31 Aug 2018, In : Acta Paediatrica. 107, 8, p. 1370-1378 8 p.Research output: Contribution to journal › Article
Open Access
File
Folic Acid
Emotional Intelligence
Psychology
Pregnancy
Mothers
Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial
Caffrey, A., Irwin, R. E., McNulty, H., Strain, JJ., Lees Murdock, D., McNulty, B., Ward, M., Walsh, C. & Pentieva, K., 9 Apr 2018, In : American Journal of Clinical Nutrition. 107, 4, p. 566-575 9 p.Research output: Contribution to journal › Article
Open Access
File
Third Pregnancy Trimester
Second Pregnancy Trimester
DNA Methylation
Folic Acid
Epigenomics