Personal profile
Biography
QUALIFICATIONS
PhD in Molecular Biology
MEd in Higher Education Practice
BSc(Hons) in Biochemistry
RESEARCH INTERESTS
Translational research in Dr McKenna's laboratory is focused on the role of microRNAs (miRNAs) in disease. His main disease focus is prostate cancer and he is investigating how tumour hypoxia and epigenetic regulation leads to the abnormal expression of several miRNAs which drives cancer progression. The functionality and novel targets of selected miRNAs are being studied to improve the diagnosis, prognosis and potential therapeutic intervention of this disease, with particular emphasis on developing miRNA serum profiling as a valuable clinical tool for cancer and many other disorders. He is also involved in collaborative projects investigating the role of microRNAs in Cardiovascular Disease and Glaucoma.
Dr McKenna's research is aligned with the Genomic Medicine strategic initiatives at Ulster University, and team members collaborate externally with a number of colleagues in academia, industry and clinical institutions.
TEACHING INTERESTS
Dr McKenna contributes to teaching on a number of on-campus and distance-learning undergraduate and postgraduate courses in Biomedical Sciences at Ulster University. He is module co-ordinator for Haematology modules at BSc, PgCert and MSc level, and also contributes to modules on Molecular Pathology of Disease, Stem Cell Biology, Biomedical Professional Practice, Study Skills, as well as supervising final year student (Hons) projects. He has several years experience as Placement Tutor for students studying on the BSc(Hons) Biomedical Sciences DPP(Path) programme.
ADMINISTRATIVE AND PROFESSIONAL ACTIVITIES
Ulster University
Associate Head of School (2020 – )
Academic Division Head, Bio and Healthcare Sub-School (2018 – 20)
Biomedical Sciences Global Engagement & Academic Recruitment (2017 – )
UU Faculty of Life & Health Sciences Committee on Employability (2015 – )
Chair of Employers’ Liaison Group (ELG) Committee, Biomedical Sciences (2011-18 )
BMSRI Cell Technologies Core Facility Unit Coordinator (2014-15)
External Representation
HSC R&D Doctoral Fellowship Scheme, Panel Member (2019)
Genomics, Editor (2018 – )
NI Institute of Biomedical Sciences Branch Member (2018 – )
NI Biobank Steering Committee (2018 – )
NI Pathology Network Committee Member (2018 – )
Irish Association of Cancer Research Senior Council (2017 – )
Royal Society of Biology Northern Ireland Branch Committee Member (2015 – )
Genetics Society Northern Ireland Local Representative (2013 – )
Chair of Cancer Translational Research Group (CTRG), Public Health Agency (2015-16)
Invited Ad-hoc Reviewer: including MRC, OUP, Genomics, Oncogene, Molecular Cancer.
Professional Membership
Senior Fellow of the Higher Education Academy (SFHEA)
Fellow of the Royal Society of Biology (FRSB)
Fellow of the Centre for Higher Education Research and Practice (FCHERP) at UU
Chartered Science Teacher (CSciTeach)
Chartered Biologist (CBiol)
Genetics Society Member
PUBLIC OUTREACH & CIVIC CONTRIBUTION
Dr McKenna is a registered member of the STEM Ambassador programme in Northern Ireland which aims to inspire and engage young people about the value of STEM subjects in daily life. He has a long-standing collaboration with the W5 Science Discovery Centre, Belfast to deliver STEM activities for schools and the general public. He has made well-received contributions to the annual NI Science Festival, RTE Brainstorm and a number of other initiatives promoting Public Engagement in Science.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 9 Industry, Innovation, and Infrastructure
Fingerprint
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Collaborations and top research areas from the last five years
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miR‐210 is induced by hypoxia and regulates neural cell adhesion molecule in prostate cells
Angel, C. Z., Lynch, S. M., Nesbitt, H., McKenna, M. M., Walsh, C. & McKenna, D. J., 9 Jun 2020, In: Journal of Cellular Physiology. 235, 9, p. 6194-6203 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Link opens in a new tab Citations (Scopus)238 Downloads (Pure) -
Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression
Nesbitt, H., Byrne, N. M., Williams, S. N., Ming, L., Worthington, J., Errington, R. J., Patterson, L. H., Smith, P. J., McKeown, S. & McKenna, D., 30 Apr 2017, In: Clinical Cancer Research. 23, 7, p. 1797-1808 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Link opens in a new tab Citations (Scopus)96 Downloads (Pure) -
Regulation of miR-200c and miR-141 by methylation in prostate cancer
Lynch, S., O'Neill, K. M., McKenna, M. M., Walsh, C. & McKenna, D. J., 15 Sept 2016, In: The Prostate. 76, 13, p. 1146-1159Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Link opens in a new tab Citations (Scopus)119 Downloads (Pure) -
Appetite-regulating hormones-leptin, adiponectin and ghrelin-and the development of prostate cancer: a systematic review and exploratory meta-analysis.
Angel, Z., Iguacel, I., Mullee, A., Guha, N., Wasson, R., McKenna, D. J., Gunter, M., Smelov, V. & Huybrechts, I., 31 Mar 2020, In: Prostate Cancer and Prostatic Diseases. 23, p. 11-23 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Link opens in a new tab Citations (Scopus)389 Downloads (Pure) -
Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition
Byrne, N., Nesbitt, H., Ming, L., McKeown, S., Worthington, J. & McKenna, D., 8 Mar 2016, In: BRITISH JOURNAL OF CANCER. epubResearch output: Contribution to journal › Article › peer-review
Open Access42 Link opens in a new tab Citations (Scopus)
Prizes
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ABC Life Science Forum (External organisation)
Mc Kenna, D. (Chair)
2020Activity: Membership › Membership of network
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NI Biobank (External organisation)
Mc Kenna, D. (Chair)
2018Activity: Membership › Membership of committee
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Pathology Network NI (External organisation)
Mc Kenna, D. (Chair)
2018Activity: Membership › Membership of network
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Institute of Biomedical Science NI Branch (External organisation)
Mc Kenna, D. (Chair)
2018Activity: Membership › Membership of committee
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Irish Association of Cancer Research (External organisation)
Mc Kenna, D. (Member)
2017 → …Activity: Membership › Membership of council
Press/Media
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NI SCIENCE FESTIVAL 2022: THE SCIENCE OF MONSTERS
23/02/22 → 24/02/22
2 Media contributions
Press/Media: Public Engagement Activities
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NI LIBRARIES TURNING HEADS : Ginger Genetics
24/09/21
2 Media contributions
Press/Media: Public Engagement Activities
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NI SCIENCE FESTIVAL 2021 HEALTHY AGEING
19/02/21
1 Media contribution
Press/Media: Public Engagement Activities
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RTE BRAINSTORM : What makes Christmas songs so Christmassy?
18/12/20
1 Media contribution
Press/Media: Public Engagement Activities
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RTE BRAINSTORM : It's a Wonderful Life
10/12/20
1 Media contribution
Press/Media: Public Engagement Activities
Profiles
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Development of a docetaxel-loaded implantable device for the localised treatment of prostate cancer
McConville, C. (PI) & McKenna, D. (CoI)
1/09/25 → 31/08/28
Project: Research
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'Relaxin' the pressure in glaucoma
Willoughby, C. (PI) & McKenna, D. (CoI)
2/10/23 → 1/10/26
Project: Research
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Development of a Disease Modifying Biologic Therapy for Glaucoma.
Willoughby, C. (PI), Callan, B. (CoI) & McKenna, D. (CoI)
1/10/22 → 1/09/26
Project: Research
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The Role of NOX4 and finroredoximiRs in glaucoma therapeutic opportunities?
Nesbit, A. (CoI), McKenna, D. (CoI) & Willoughby, C. (PI)
1/10/18 → 1/04/23
Project: Research
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PhD entitled Diagnostic classifier(s) for early risk stratification of patients who present with prostate cancer symptom- ref 118RDRH
Moore, T. (CoI) & McKenna, D. (PI)
5/02/18 → 4/02/21
Project: Research