• Northlands Road, Magee Campus

    BT48 7JL Londonderry

    United Kingdom

  • 1115 Citations
  • 16 h-Index
20022020

Research output per year

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Personal profile

Biography

After his Biochemistry degree, Dr David Gibson worked at Randox Laboratories Ltd, where he was responsible for designing and commercialising novel biochip array diagnostic tests.

He was awarded a PhD in 2001 from the Centre for Cancer Research and Cell Biology, Queen’s University Belfast (QUB), for research which exposed the role of cysteine proteinases in brain tumour invasion.

During a Wellcome Trust Fellowship Dr Gibson investigated the role of inflammation in a hypoxia driven model of diabetic retinopathy at the Centre of Vision and Vascular Science, QUB.

Since 2003 Dr Gibson focused his research efforts on the discovery and validation of protein biomarkers which could improve the management of arthritis patients.

During his time at the Rooney laboratory in the Centre of Infection and Immunity, QUB he spearheaded the use of proteomic and bioinformatics strategies to discover clinically useful biomarker candidates. He also identified post translational modifications in the Vitamin D binding protein that may act as a modulator of inflammation in juvenile arthritis patients.

In 2009, Dr Gibson was awarded a prestigious travel fellowship from Arthritis Research UK to conduct mass spectrometry based research at the Duncan laboratory at the University of Colorado, Denver over two years.

 

 

Research Interests

 

In 2013 Dr Gibson took up his post as Lecturer in Stratified Medicine and his research is focused on adult rheumatoid arthritis (RA). He is particularly interested in the development of new prognostic and predictive tools to improve the clinical management of arthritis patients.

He employs novel mass spectrometry based methods to robustly identify and quantify disease associated proteins in blood. He is also interested in the application of protein array technologies for autoantibody screening and flow cytometry in measuring B- and T-cell activation.

He has established research programmes in three key areas:
1. Biomarkers of response to disease modifying anti-rheumatic drugs.
2. Mechanisms of cannabinoid compounds on inflammation and pain in a model of arthritis.
3. Alternate blood sampling methods to support home based monitoring of arthritis.

Ultimately, Dr Gibsons group will develop novel monitoring tools to help clinicians target those patients who do not respond well to current therapeutics or develop drug resistance over time. This could allow earlier more effective treatments in RA patients, thus preventing joint damage and reducing disability.

 

Teaching Interests

 

1. Introduction to Pharmacogenomics and Stratified Medicine
2. Inflammatory and Immunological Disease
3. Genomics, Proteomics and Metabolomics
4. Disease and Treatment 2

Administrative Roles

BSc Associate Course Director

Keywords

  • RZ Other systems of medicine
  • QH301 Biology

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Research Output

Keratinocyte Growth-Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

Shyamsundar, M., McAuley, DF., Ingram, RJ., Gibson, D., O'Kane, D., McKeown, ST., Edwards, A., Taggart, C., Elborn, JS., Calfee, CS., Matthay, MA. & O'Kane, CM., 15 Jun 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 12, p. 1520-1529 10 p.

Research output: Contribution to journalArticle

  • 54 Citations (Scopus)

    Antiviral antibody profiling by high‐density protein arrays

    Bian, X., Wiktor, P., Kahn, P., Brunner, A., Khela, A., Karthikeyan, K., Barker, K., Yu, X., Magee, M., Wasserfall, CH., Gibson, D., Rooney, ME., Qiu, J. & LaBaer, J., 16 Jun 2015, In : Proteomics. 15, 12, p. 2136-2145 13 p.

    Research output: Contribution to journalArticle

  • 18 Citations (Scopus)

    Proteomic profile of cystic fibrosis sputum cells in adults chronically infected with Pseudomonas aeruginosa

    Pattison, SH., Gibson, DS., Johnston, E., Peacock, S., Rivera, K., Tunney, MM., Pappin, DJ. & Elborn, JS., 5 Jul 2017, In : European Respiratory Journal. 50, 1, p. 1-11 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    12 Downloads (Pure)

    Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease

    Finnegan, S., Robson, J., Scaife, C., McAllister, C., Pennington, SR., Gibson, D. & Rooney, ME., 13 Jan 2014, In : Arthritis Research and Therapy. 16, 1, R8.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Citations (Scopus)

    A clinically based protein discovery strategy to identify potential biomarkers of response to anti‐TNF‐α treatment of psoriatic arthritis

    Collins, ES., Butt, AQ., Gibson, DS., Dunn, M., Fearon, U., van Kuijk, AW., Gerlag, DM., Pontifex, E., Veale, DJ., Tak, PP., Fitzgerald, O. & Pennington, SR., 1 Jun 2016, In : PROTEOMICS - Clinical Applications. 10, 6, p. 645-662 18 p.

    Research output: Contribution to journalArticle

  • 9 Citations (Scopus)

    Prizes

  • Basic Science Award

    Niamh Callan (Recipient), 2016

    Prize

  • Activities

    • 1 Oral presentation

    Cannabinoids and health: from supplements to medicines

    David Gibson (Speaker)
    6 Oct 2019

    Activity: Talk or presentationOral presentation

    Press / Media

    The therapeutic potential of the endocannabinoid system

    David Gibson

    26/11/19

    1 Media contribution

    Press/Media: Expert Comment

    Cannabinoids and health – from supplements to medicines

    David Gibson

    7/10/19

    1 Media contribution

    Press/Media: Expert Comment

    Irish Research Suggests Cannabis Treats Arthritis

    David Gibson

    10/05/19

    1 Media contribution

    Press/Media: Expert Comment

    All you ever wanted to know about arthritis

    David Gibson

    18/01/19

    1 Media contribution

    Press/Media: Expert Comment

    Thesis

    Discovery of circulating DMARD response biomarkers in rheumatoid arthritis

    Author: Eakin, A., Apr 2018

    Supervisor: Gibson, D. (Supervisor) & Bjourson, A. (Supervisor)

    Student thesis: Doctoral Thesis

    File

    Towards a personalised medicine strategy to reduce prostate cancer risk in men

    Author: Yankova, E., May 2018

    Supervisor: Mc Dowell, A. (Supervisor) & Gibson, D. (Supervisor)

    Student thesis: Doctoral Thesis

    File