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Charlotte Moffett

Dr

  • Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 245 Citations
  • 10 h-Index
20142019
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Research Output 2014 2019

  • 245 Citations
  • 10 h-Index
  • 26 Article
  • 1 Conference contribution
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Article
2019
Oxyntomodulin
Cell Transdifferentiation
Insulin
Glucose
Peptides
2 Citations (Scopus)
Vasopressin Receptors
Arginine Vasopressin
Insulin-Secreting Cells
Glucose
Survival
2018
4 Citations (Scopus)

Expression of Gastrin Family Peptides in Pancreatic Islets and Their Role in β-Cell Function and Survival

Khan, D., Vasu, S., Moffett, C., Irwin, N. & Flatt, P., 12 Jan 2018, In : Pancreas. 47, 2, p. 190-199

Research output: Contribution to journalArticle

Open Access
Gastrins
Islets of Langerhans
Cell Survival
Cholecystokinin
Peptides
5 Citations (Scopus)

Identification of Components in Frog Skin Secretions with Therapeutic Potential as Antidiabetic Agents

Conlon, JM., Moffett, C., Leprince, J. & Flatt, P., 24 Feb 2018, In : Methods in Molecular Biology. 1719, p. 319-333

Research output: Contribution to journalArticle

Open Access
Hypoglycemic Agents
Skin
Peptides
Insulin
Glucose
4 Citations (Scopus)

Oxytocin is present in islets and plays a role in beta-cell function and survival

Mohan, S., Khan, D., Moffett, C., Irwin, N. & Flatt, P., 3 Feb 2018, In : Peptides. 100, p. 260-268

Research output: Contribution to journalArticle

Open Access
Oxytocin
Cell Survival
Insulin
Oxytocin Receptors
Rodentia
2017
8 Citations (Scopus)

Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents

Owolabi, BO., Musalea, V., Ojo, OO., Moffett, C., McGahon, MK., Curtis, TM., Conlon, JM., Flatt, P. & Abdel-Wahab, YHA., 7 Apr 2017, In : Biochimie. 138, p. 1-12

Research output: Contribution to journalArticle

Open Access
File
Pipidae
Insulin
Peptides
Anura
Therapeutics
5 Citations (Scopus)

Anti-diabetic actions of esculentin-2CHa(1–30) and its stable analogues in a diet-induced model of obesity-diabetes

Vasu, S., Ojo, O., Moffett, C., Conlon, JM., Flatt, P. & Abdel-Wahab, Y., 23 Aug 2017, In : Amino Acids. 49, 10, p. 1705-1717

Research output: Contribution to journalArticle

Open Access
Obesity
Diet
Peptides
High Fat Diet
Blood Glucose
8 Citations (Scopus)
Open Access
Glucagon-Like Peptide 2
Islets of Langerhans
Cell Survival
Cells
Streptozocin
8 Citations (Scopus)

Esculentin-2CHa(1-30) and its analogues: stability and mechanisms of insulinotropic action.

Vasu, S., McGahon, M., Moffett, C., Curtis, T., Conlon, JM., Abdel-Wahab, YHA. & Flatt, P., 1 Mar 2017, In : Journal of Endrocrinology. 232, 3, p. 423-435

Research output: Contribution to journalArticle

Open Access
File
Insulin
KATP Channels
Cell Membrane
Diazoxide
Glucose
13 Citations (Scopus)
Open Access
File
Pancreatic Polypeptide
Neuropeptide Y
Cell Survival
Neuropeptide Y Receptors
Peptides
11 Citations (Scopus)
Open Access
Islets of Langerhans
Cell Survival
Neurotensin
Cells
Streptozocin
13 Citations (Scopus)

Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice

Millar, P., Pathak, N., Parthsarathy, V., Bjourson, AJ., O'Kane, M., Pathak, V., Moffett, C., Flatt, P. & Gault, V. A., 23 Jun 2017, (Accepted/In press) In : Journal of Endrocrinology. 234, 3, p. 255-267

Research output: Contribution to journalArticle

Open Access
Neuroprotective Agents
Glucose
Glucagon-Like Peptide 1
Insulin
Energy Intake
2016
12 Citations (Scopus)

Beneficial metabolic actions of a stable GIP agonist following pre-treatment with a SGLT2 inhibitor in high fat fed diabetic mice.

Millar, PJ., Pathak, V., Moffett, C., Pathak, NM., Bjourson, AJ., OKane, MJ., Flatt, P. & Gault, V., 15 Jan 2016, In : Molecular and Cellular Endocrinology. 420, p. 37-45 8 p.

Research output: Contribution to journalArticle

Open Access
Sodium-Glucose Transport Proteins
Fats
Glucose
Peptides
Insulin
3 Citations (Scopus)
Open Access
File
Glucagon-Secreting Cells
Glucagon-Like Peptide 1
Cytotoxins
Coculture Techniques
Glucagon

Evaluation of the role of N-methyl-D-aspartate (NMDA) receptors in insulin secreting beta-cells

Patterson, S., Irwin, N., Gou-Parke, H., Moffett, C., Scullion, SM., Flatt, P. & McClenaghan, N., 15 Jan 2016, In : European Journal of Pharmacology. 771, p. 107-113

Research output: Contribution to journalArticle

Open Access
Insulin-Secreting Cells
N-Methyl-D-Aspartate Receptors
Homocysteine
Insulin
N-Methylaspartate
29 Citations (Scopus)
Open Access
File
Peptide YY
Rodentia
Cell Survival
Streptozocin
Glucagon-Like Peptide 1
13 Citations (Scopus)

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

Ojo, OO., Srinivasan, DK., Owolabi, BO., McGahon, MK., Moffett, C., Curtis, TM., Conlon, JM., Flatt, P. & Abdel-Wahab, Y., 1 Aug 2016, In : Biological Chemistry. 397, 8, p. 753-764

Research output: Contribution to journalArticle

Open Access
Nutrition
Insulin Resistance
Obesity
Insulin
Diet
2015
18 Citations (Scopus)
Open Access
Glucagon-Secreting Cells
Glucagon-Like Peptide 1
Palmitates
Cytotoxic T-Lymphocytes
Cats
7 Citations (Scopus)
Open Access
High Fat Diet
Cognition
Gene Expression
Sirolimus
Knockout Mice
3 Citations (Scopus)

Evaluation of the role of N-methyl-d-aspartate (NMDA) receptors in insulin secreting beta-cells

Patterson, S., Irwin, N., Gou-Parke, H., Moffett, C., Scullion, SM., Flatt, P. & McClenaghan, N., 10 Dec 2015, In : European Journal of Pharmacology. 771, p. 107-113

Research output: Contribution to journalArticle

Open Access
Insulin-Secreting Cells
Homocysteine
Insulin
Aspartic Acid
Dizocilpine Maleate
11 Citations (Scopus)

Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice

Moffett, C., Vasu, S. & Flatt, P., 14 Feb 2015, In : Biochim Biophys Acta. 1850, 6, p. 1206-1214

Research output: Contribution to journalArticle

Open Access
Gastric Inhibitory Polypeptide
Glucagon-Like Peptide 1
Fats
High Fat Diet
Islets of Langerhans
3 Citations (Scopus)

Pharmacological characterization and antidiabetic activity of a long-acting glucagon-like peptide-1 analogue conjugated to an antithrombin III-binding pentasaccharide.

Patterson, S., de Kort, M., Irwin, N., Moffett, C., Dokter, WH., Bos, ES., Miltenburg, AM. & Flatt, P., 1 Aug 2015, In : Diabetes Obesity and Metabolism. 17, 8, p. 760-770

Research output: Contribution to journalArticle

Open Access
Glucagon-Like Peptide 1
Antithrombin III
Hypoglycemic Agents
Pharmacology
Insulin
16 Citations (Scopus)
Open Access
Islets of Langerhans
Glucagon-Like Peptide 1
Insulin
Glucose
Peptides
7 Citations (Scopus)

Responses of GLP1-secreting L-cells to cytotoxicity resemble pancreatic β-cells but not α-cells.

Vasu, S., Moffett, C., McClenaghan, N. & Flatt, P., 1 Feb 2015, In : Journal of Molecular Endocrinology. 54, 1, p. 91-104

Research output: Contribution to journalArticle

Open Access
Insulin-Secreting Cells
Cytotoxic T-Lymphocytes
Cytotoxins
Streptozocin
Antioxidants
4 Citations (Scopus)

Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes.

Irwin, N., Patterson, S., de Kort, M., Moffett, C., Wisse, JA., Dokter, WH., Bos, ES., Miltenburg, AM. & Flatt, P., 1 Aug 2015, In : ChemMedChem. 10, (8), p. 1424-1434.

Research output: Contribution to journalArticle

Open Access
Glucagon-Like Peptide 1
Medical problems
Peptides
Glycols
Antithrombin III
2014
38 Citations (Scopus)

Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress.

Vasu, S., Thorens, B., Flatt, P. & Moffett, C., 26 Jun 2014, In : PLoS ONE. 9, 6, p. e101005

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Insulin Resistance
Hydrocortisone
Streptozocin
Incretins