Personal profile
Biography
After graduating with an honours degree in Biochemistry from the University of Oxford, Andrew gained his PhD from the University of London with the Imperial Cancer Research Fund, before joining Professor Kay Davies at the Royal Postgraduate Medical School, London and then the Institute of Molecular Medicine, Oxford. Here he was part of the team, which identified mutations in the Survival Motor Neurone (SMN) gene as causative of Spinal Muscular Atrophy.
He returned to London, joining the group of Professor Raj Thakker at the Clinical Sciences Centre, Hammersmith Hospital and relocated with him to Oxford firstly, as a senior postdoctoral researcher and then as a University Research Lecturer uncovering the genetic causes of disorders of calcium metabolism.
Both as the senior scientist in the Academic Endocrine Unit and in his own right, Andrew was successful in attracting peer-reviewed funding from bodies such as the MRC, EU and ARUK.
His expertise, technical knowledge and insight in the field was widely recognised and he was been regularly invited to speak at international (American Society of Bone and Mineral Research, EMBO workshops on GATA factors, Translational Research in Europe Applied Technologies for Osteoarthritis (EU Framework 7) Consortium meetings) and national conferences (British Endocrine Society, Bone Research Society).
In 2013, Andrew joined the Vision Research Group Research within the Genomic Medicine at Ulster University as a Senior Lecturer in Molecular Biology.
Working with Tara Moore, Andrew brings his expertise in identifying the underlying genetic causes of human disease to the development of gene editing and gene silencing technologies for inherited eye diseases. His work has been disseminated worldwide in invited guest lectures and workshops at internationally eye conferences (ARVO and ISER), co-authored peer reviewed publications in high impact peer reviewed journals and contributions to a number of book chapters. Andrew has a consistent record of publication in high quality, peer-reviewed journals (Nature, New England Journal of Medicine, Nature Genetics, Journal of Clinical Investigation, Human Molecular Genetics, Journal of Biological Chemistry, Journal of Controlled Release, Molecular Therapy).
Andrew collaborates widely with colleagues in both Academia (University College London; Queen’s University Belfast; Trinity College, Dublin; University of Dundee, Aarhus University, Denmark; Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; University of Cologne, Germany) and industry (Avellino Labs, USA, Sisaf Ltd UK, Almac Discovery)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 9 Industry, Innovation, and Infrastructure
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Collaborations and top research areas from the last five years
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Validation of a stall‐side immunoglobulin assay for use in equine reproductive management
Moore, L., McLain, A., McDowell, S. H., Ledgerwood, C. J., Bailie, E., Nesbit, M. A. & Moore, T., 28 Apr 2026, (Published online) In: Equine Veterinary Journal. p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery
McLain, A., Kowalczyk, A., Baran-Rachwalska, P., Sutera, F. M., Robertson, L. J., Nielsen, N. S., Enghild, J. J., Cobice, D., Bonelli, F., Barbaro, V., Ferrari, S., Patterson, B., Moore, L., Marshall, J., Nesbit, M. A. & Moore, T., 10 Jun 2025, In: Journal of Controlled Release. 382, p. 1-22 22 p., 113681.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)8 Downloads (Pure) -
Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers
McLain, A., Saffie-Siebert, S. R., Nielsen, N. S., Patterson, B., Scavenius, C., Enghild, J. J., Marshall, J., Baran-Rachwalska, P., Sutera, F. M., Welsh, M., Moore, L., Willoughby, C., Nesbit, M. A. & Moore, T. C. B., 10 Dec 2025, In: Journal of Controlled Release. 388, part 1, p. 1-18 18 p., 114315.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)25 Downloads (Pure) -
Validation of a stall-side Immunoglobin assay for use in equine reproductive management
Moore, L., McLain, A., McDowell, S., Ledgerwood, C., Bailie, E., Nesbit, A. & Moore, T., 29 Oct 2025, (Published online) p. 1-4, 4 p.Research output: Working paper › Preprint
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Appraisal of Cardiovascular Risk Factors, Biomarkers, and Ocular Imaging in Cardiovascular Risk Prediction
Moore, J. S., Nesbit, A. & Moore, T., 27 Jul 2023, (Published online) In: Current Cardiology Reviews. 19, 6, p. 72-81 10 p., 37497700.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)55 Downloads (Pure)
Datasets
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Validation of a stall‐side immunoglobulin assay for use in equine reproductive management
McDowell, S. (Creator), McLain, A. (Creator), Bailie, E. (Creator), Nesbit, M. A. (Creator) & Moore, T. C. B. (Creator), Ulster University, 22 Apr 2026
DOI: 10.21251/d6f9f476-5b6b-45a5-8e0c-d4ace7ebb725
Dataset
File
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Mini symposium proposal, Emerging gene-driven therapies for anterior segment disease
Moore, T. (Speaker) & Nesbit, M. A. (Speaker)
2019 → …Activity: Talk or presentation › Invited talk
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ARVO Ethical Challenges and Solutions for CRISPR Treatment in Human
Moore, T. (Speaker) & Nesbit, M. A. (Speaker)
2019 → …Activity: Talk or presentation › Invited talk
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ARVO
Moore, T. (Participant), Christie, K. (Participant), DeDionisio, L. (Participant), Chao-Shern, C. (Participant), Blighe, K. (Participant) & Nesbit, M. A. (Participant)
29 Apr 2018Activity: Participating in or organising an event › Participating in a conference, workshop, ...
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CiC Conference
Moore, T. (Participant), Brennan, P. (Participant), Finlay, D. (Participant), Spence, M. (Participant), Awuah, A. (Participant), McLaughlin, J. (Participant), Moore, J. (Participant), Nesbit, M. A. (Participant), Trucco, E. (Participant) & Wang, R. (Participant)
Sept 2017 → …Activity: Participating in or organising an event › Participating in a conference, workshop, ...
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12th European Molecular Imaging Meeting
Moore, T. (Participant), Mairs, L. (Participant), Cobice, D. (Participant), MacKay, L. (Participant), Christie, K. (Participant) & Nesbit, M. A. (Participant)
Apr 2017Activity: Participating in or organising an event › Participating in a conference, workshop, ...
Profiles
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Gene therapy for genetic eye disease: years 5 and 6
Moore, T. (PI) & Nesbit, A. (CoI)
1/11/20 → 31/05/28
Project: Research
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Gene therapy for genetic eye disease: years 3 and 4
Nesbit, A. (CoI) & Moore, T. (PI)
1/06/18 → 31/05/28
Project: Research
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Eye organoculture to progress topical siRNA therapy for Avellino dystrophy
Robertson, L. (PI), Nesbit, A. (CoI) & Moore, T. (CoI)
1/01/22 → 31/01/25
Project: Research