• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 945 Citations
  • 14 h-Index
20102020

Research output per year

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Personal profile

Biography

After graduating with an honours degree in Biochemistry from the University of Oxford, Andrew gained his PhD from the University of London with the Imperial Cancer Research Fund, before joining Professor Kay Davies at the Royal Postgraduate Medical School, London and then the Institute of Molecular Medicine, Oxford. Here he was part of the team, which identified mutations in the Survival Motor Neurone (SMN) gene as causative of Spinal Muscular Atrophy.He returned to London, joining the group of Professor Raj Thakker at the Clinical Sciences Centre, Hammersmith Hospital and relocated with him to Oxford firstly, as a senior postdoctoral researcher uncovering the genetic causes of disorders of calcium metabolism.Andrew has a consistent record of publication in high quality, peer-reviewed journals (Nature, New England Journal of Medicine, Nature Genetics, Journal of Clinical Investigation, Human Molecular Genetics, Journal of Biological Chemistry).Both as the senior scientist in the Academic Endocrine Unit and in his own right, Andrew was successful in attracting peer-reviewed funding from bodies such as the MRC, EU and ARUK. His expertise, technical knowledge and insight in the field is widely recognised and he has been regularly invited to speak at international (American Society of Bone and Mineral Research, EMBO workshops on GATA factors, Translational Research in Europe Applied Technologies for Osteoarthritis (EU Framework 7) Consortium meetings) and national conferences (British Endocrine Society, Bone Research Society).Andrew has recently been recruited as a Senior Lecturer in Molecular Biology at Ulster University where he has joined the Vision Research GroupResearch InterestsMechanisms of lens homeostasis in the development of cataractsGenetics of anterior eye diseaseTeaching InterestsApplied Genetics, Molecular Biology

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Research Output

  • 945 Citations
  • 14 h-Index
  • 37 Article
  • 2 Conference contribution
  • 1 Abstract
  • 1 Review article

CRISPR/Cas9 gene editing demonstrates metabolic importance of GPR55 in the modulation of GIP release and pancreatic beta cell function.

McCloskey, A. G., Miskelly, M. G., Moore, T. C. B., Nesbit, M. A., Christie, K., Owolabi, A., Flatt, PR. & McKillop, A., 31 Mar 2020, In : Peptides. 125, 170251.

Research output: Contribution to journalReview article

  • Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism

    Gaynor, K. U., Grigorieva, I. V., Mirczuk, S. M., Piret, S. E., Kooblall, K. G., Stevenson, M., Rizzoti, K., Bowl, M. R., Nesbit, M. A., Christie, P. T., Fraser, W. D., Hough, T., Whyte, M. P., Lovell-Badge, R. & Thakker, R. V., 29 Feb 2020, In : Endocrine Connections. 9, 2, p. 173-186 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Capsid Engineering Overcomes Barriers Toward Adeno-Associated Virus Vector-Mediated Transduction of Endothelial Cells

    Zhang, L., Rossi, A., Lange, L., Meumann, N., Koitzsch, U., Christie, K., Nesbit, M. A., Moore, T. C. B., Hacker, U. T., Morgan, M., Hoffmann, D., Zengel, J., Carette, J. E., Schambach, A., Salvetti, A., Odenthal, M. & Büning, H., 23 Sep 2019, In : Human Gene Therapy. 30, 10, p. 1284-1296 13 p.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    Effective in vivo topical delivery of siRNA and gene silencing in intact corneal epithelium using a modified cell penetrating peptide

    Schiroli, D., Gomara, M. J., Maurizi, E., Atkinson, S. D., Mairs, L., Christie, K., Cobice, D., McCrudden, C. M., Nesbit, M. A., Haro, I. & Moore, T. C. B., 6 Sep 2019, In : Molecular Therapy - Nucleic Acids. 17, p. 891-906 16 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Downloads (Pure)

    Late-Onset Lattice Corneal Dystrophy Associated TGFBI p.H626R Mutation in Members of a Canadian Family

    Chao-Shern, C., DeDionisio, L., Chan, C., Nesbit, M. A. & McMullen, C. B. T., 1 Dec 2019, In : Canadian Journal of Ophthalmology. 54, 6, p. e308-e311 4 p.

    Research output: Contribution to journalArticle

  • Activities

    • 14 Participating in a conference, workshop, ...
    • 2 Invited talk

    ARVO Ethical Challenges and Solutions for CRISPR Treatment in Human

    Tara Moore (Speaker), M. Andrew Nesbit (Speaker)
    2019 → …

    Activity: Talk or presentationInvited talk

    Mini symposium proposal, Emerging gene-driven therapies for anterior segment disease

    Tara Moore (Speaker), M. Andrew Nesbit (Speaker)
    2019 → …

    Activity: Talk or presentationInvited talk

    ARVO

    Tara Moore (Participant), Kathleen Christie (Participant), Larry DeDionisio (Participant), Connie Chao-Shern (Participant), Kevin Blighe (Participant), M. Andrew Nesbit (Participant)
    29 Apr 2018

    Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

    CiC Conference

    Tara Moore (Participant), Paul Brennan (Participant), D Finlay (Participant), Mark Spence (Participant), Agnes Awuah (Participant), James McLaughlin (Participant), Jonathan Moore (Participant), M. Andrew Nesbit (Participant), Emanuele Trucco (Participant), Ruixuan Wang (Participant)
    Sep 2017 → …

    Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

    12th European Molecular Imaging Meeting

    Tara Moore (Participant), Laura Mairs (Participant), Diego Cobice (Participant), Logan MacKay (Participant), Kathleen Christie (Participant), M. Andrew Nesbit (Participant)
    Apr 2017

    Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

    Thesis

    Development of Partner Diagnostics and Therapeutics for Genetic Eye Disease

    Author: Chao-Shern, C., Aug 2019

    Supervisor: Nesbit, M. A. (Supervisor), Thompson, P. (Supervisor) & Moore, T. C. B. (Supervisor)

    Student thesis: Doctoral Thesis

    Evaluation of visual performance and vision questionnaires in intraocular lens implantation and laser refractive surgery

    Author: Pazo, E., Sep 2017

    Supervisor: Nesbit, M. A. (Supervisor) & Moore, T. C. B. (Supervisor)

    Student thesis: Doctoral Thesis

    File

    Extending the conventional limits for the correction of high ametropia by corneal laser refractive surgery

    Author: Archer, T., May 2018

    Supervisor: Nesbit, M. A. (Supervisor), Moore, T. C. B. (Supervisor) & Reinstein, D. Z. (Supervisor)

    Student thesis: Doctoral Thesis

    File

    Proof of concept of CRISPR/Cas9 to treat corneal dystrophies

    Author: Christie, K., Oct 2018

    Supervisor: Nesbit, M. A. (Supervisor), Moore, T. C. B. (Supervisor) & Courtney, D. (Supervisor)

    Student thesis: Doctoral Thesis