• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 888 Citations
  • 14 h-Index
20102019
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Personal profile

Biography

After graduating with an honours degree in Biochemistry from the University of Oxford, Andrew gained his PhD from the University of London with the Imperial Cancer Research Fund, before joining Professor Kay Davies at the Royal Postgraduate Medical School, London and then the Institute of Molecular Medicine, Oxford. Here he was part of the team, which identified mutations in the Survival Motor Neurone (SMN) gene as causative of Spinal Muscular Atrophy.He returned to London, joining the group of Professor Raj Thakker at the Clinical Sciences Centre, Hammersmith Hospital and relocated with him to Oxford firstly, as a senior postdoctoral researcher uncovering the genetic causes of disorders of calcium metabolism.Andrew has a consistent record of publication in high quality, peer-reviewed journals (Nature, New England Journal of Medicine, Nature Genetics, Journal of Clinical Investigation, Human Molecular Genetics, Journal of Biological Chemistry).Both as the senior scientist in the Academic Endocrine Unit and in his own right, Andrew was successful in attracting peer-reviewed funding from bodies such as the MRC, EU and ARUK. His expertise, technical knowledge and insight in the field is widely recognised and he has been regularly invited to speak at international (American Society of Bone and Mineral Research, EMBO workshops on GATA factors, Translational Research in Europe Applied Technologies for Osteoarthritis (EU Framework 7) Consortium meetings) and national conferences (British Endocrine Society, Bone Research Society).Andrew has recently been recruited as a Senior Lecturer in Molecular Biology at Ulster University where he has joined the Vision Research GroupResearch InterestsMechanisms of lens homeostasis in the development of cataractsGenetics of anterior eye diseaseTeaching InterestsApplied Genetics, Molecular Biology

Fingerprint Dive into the research topics where Andrew Nesbit is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Mutation Medicine & Life Sciences
Calcium-Sensing Receptors Medicine & Life Sciences
Protein Subunits Medicine & Life Sciences
Ethylnitrosourea Medicine & Life Sciences
GTP-Binding Proteins Medicine & Life Sciences
Clustered Regularly Interspaced Short Palindromic Repeats Medicine & Life Sciences
Sigma Factor Medicine & Life Sciences
Hypocalcemia Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2010 2019

  • 888 Citations
  • 14 h-Index
  • 37 Article
  • 2 Conference contribution
1 Citation (Scopus)

Capsid Engineering Overcomes Barriers Toward Adeno-Associated Virus Vector-Mediated Transduction of Endothelial Cells

Zhang, L., Rossi, A., Lange, L., Meumann, N., Koitzsch, U., Christie, K., Nesbit, M. A., Moore, T. C. B., Hacker, U. T., Morgan, M., Hoffmann, D., Zengel, J., Carette, J. E., Schambach, A., Salvetti, A., Odenthal, M. & Büning, H., 23 Sep 2019, In : Human Gene Therapy. 30, 10, p. 1284-1296 13 p.

Research output: Contribution to journalArticle

Dependovirus
Capsid
Endothelial Cells
Regenerative Medicine
Genetic Therapy

Effective in vivo topical delivery of siRNA and gene silencing in intact corneal epithelium using a modified cell penetrating peptide

Schiroli, D., Gomara, M. J., Maurizi, E., Atkinson, S. D., Mairs, L., Christie, K., Cobice, D., McCrudden, C. M., Nesbit, M. A., Haro, I. & Moore, T. C. B., 6 Sep 2019, In : Molecular Therapy - Nucleic Acids. 17, p. 891-906 16 p.

Research output: Contribution to journalArticle

Open Access
File
Cell-Penetrating Peptides
Corneal Epithelium
Gene Silencing
RNA Interference
Small Interfering RNA

Late-Onset Lattice Corneal Dystrophy Associated TGFBI p.H626R Mutation in Members of a Canadian Family

Chao-Shern, C., DeDionisio, L., Chan, C., Nesbit, M. A. & McMullen, C. B. T., 30 Apr 2019, In : Canadian Journal of Ophthalmology.

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Mutation
Laser In Situ Keratomileusis
Ophthalmology
Germany

Quantitative assessment of the conjunctival microcirculation using a smartphone and slit-lamp biomicroscope

Brennan, P., McNeil, A., Jing, M., Awuah, A., Finlay, D., Blighe, K., McLaughlin, J., Wang, R., Moore, J., Nesbit, M. A., Trucco, E., Spence, M. & Moore, T. C. B., 1 Nov 2019, In : Microvascular Research. 126, p. 1-9 9 p., 103907.

Research output: Contribution to journalArticle

Microcirculation
Smartphones
Hemodynamics
Electric lamps
Blood Volume

An N-Ethyl-N-Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion

Esapa, C. T., Piret, S. E., Nesbit, M. A., Thomas, G., Coulton, L., Kumar, S., Mallon, A-M., Bellatuono, I., Brown, M., Croucher, P., Potter, P., Brown, S. DM., Cox, R. D. & Thakker, R. V., 8 Mar 2018, In : JBMR Plus. 2, 3, p. 154-163

Research output: Contribution to journalArticle

Ethylnitrosourea
Lumbar Vertebrae
Pseudogenes
Spine
Exons

Activities 2014 2019

  • 14 Participating in a conference, workshop, ...
  • 2 Invited talk

Mini symposium proposal, Emerging gene-driven therapies for anterior segment disease

Tara Moore (Speaker), M. Andrew Nesbit (Speaker)
2019 → …

Activity: Talk or presentationInvited talk

ARVO Ethical Challenges and Solutions for CRISPR Treatment in Human

Tara Moore (Speaker), M. Andrew Nesbit (Speaker)
2019 → …

Activity: Talk or presentationInvited talk

ARVO

Tara Moore (Participant), Kathleen Christie (Participant), Larry DeDionisio (Participant), Connie Chao-Shern (Participant), Kevin Blighe (Participant), M. Andrew Nesbit (Participant)
29 Apr 2018

Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

CiC Conference

Tara Moore (Participant), Paul Brennan (Participant), D Finlay (Participant), Mark Spence (Participant), Agnes Awuah (Participant), James McLaughlin (Participant), Jonathan Moore (Participant), M. Andrew Nesbit (Participant), Emanuele Trucco (Participant), Ruixuan Wang (Participant)
Sep 2017 → …

Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

12th European Molecular Imaging Meeting

Tara Moore (Participant), Laura Mairs (Participant), Diego Cobice (Participant), Logan MacKay (Participant), Kathleen Christie (Participant), M. Andrew Nesbit (Participant)
Apr 2017

Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

Thesis

Development of Partner Diagnostics and Therapeutics for Genetic Eye Disease

Author: Chao-Shern, C., Aug 2019

Supervisor: Nesbit, M. A. (Supervisor), Thompson, P. (Supervisor) & Moore, T. C. B. (Supervisor)

Student thesis: Doctoral Thesis

Evaluation of visual performance and vision questionnaires in intraocular lens implantation and laser refractive surgery

Author: Pazo, E., Sep 2017

Supervisor: Nesbit, M. A. (Supervisor) & Moore, T. C. B. (Supervisor)

Student thesis: Doctoral Thesis

File

Extending the conventional limits for the correction of high ametropia by corneal laser refractive surgery

Author: Archer, T., May 2018

Supervisor: Nesbit, M. A. (Supervisor), Moore, T. C. B. (Supervisor) & Reinstein, D. Z. (Supervisor)

Student thesis: Doctoral Thesis

File

Proof of concept of CRISPR/Cas9 to treat corneal dystrophies

Author: Christie, K., Oct 2018

Supervisor: Nesbit, M. A. (Supervisor), Moore, T. C. B. (Supervisor) & Courtney, D. (Supervisor)

Student thesis: Doctoral Thesis