• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 1093 Citations
  • 16 h-Index
20102020

Research output per year

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Personal profile

Biography

After graduating with an honours degree in Biochemistry from the University of Oxford, Andrew gained his PhD from the University of London with the Imperial Cancer Research Fund, before joining Professor Kay Davies at the Royal Postgraduate Medical School, London and then the Institute of Molecular Medicine, Oxford. Here he was part of the team, which identified mutations in the Survival Motor Neurone (SMN) gene as causative of Spinal Muscular Atrophy.He returned to London, joining the group of Professor Raj Thakker at the Clinical Sciences Centre, Hammersmith Hospital and relocated with him to Oxford firstly, as a senior postdoctoral researcher uncovering the genetic causes of disorders of calcium metabolism.Andrew has a consistent record of publication in high quality, peer-reviewed journals (Nature, New England Journal of Medicine, Nature Genetics, Journal of Clinical Investigation, Human Molecular Genetics, Journal of Biological Chemistry).Both as the senior scientist in the Academic Endocrine Unit and in his own right, Andrew was successful in attracting peer-reviewed funding from bodies such as the MRC, EU and ARUK. His expertise, technical knowledge and insight in the field is widely recognised and he has been regularly invited to speak at international (American Society of Bone and Mineral Research, EMBO workshops on GATA factors, Translational Research in Europe Applied Technologies for Osteoarthritis (EU Framework 7) Consortium meetings) and national conferences (British Endocrine Society, Bone Research Society).Andrew has recently been recruited as a Senior Lecturer in Molecular Biology at Ulster University where he has joined the Vision Research GroupResearch InterestsMechanisms of lens homeostasis in the development of cataractsGenetics of anterior eye diseaseTeaching InterestsApplied Genetics, Molecular Biology

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Research Output

CRISPR/Cas9 gene editing demonstrates metabolic importance of GPR55 in the modulation of GIP release and pancreatic beta cell function.

McCloskey, A. G., Miskelly, M. G., Moore, T. C. B., Nesbit, M. A., Christie, K., Owolabi, A., Flatt, PR. & McKillop, A., 31 Mar 2020, In : Peptides. 125, 170251.

Research output: Contribution to journalReview article

  • 1 Citation (Scopus)

    Gene Editing for Corneal Stromal Regeneration

    Moore, T. C. B., Chao-Shern, C., DeDionisio, L., Christie, K. A. & Nesbit, M. A., 16 Jun 2020, Corneal Regeneration: Methods in Molecular Biology. Ahearne, M. (ed.). New York, NY: Springer Nature, Vol. 2145. p. 59-75 17 p. (Methods in Molecular Biology; vol. 2145).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Mutation-independent allele-specific editing by CRISPR-Cas9, a novel approach to treat autosomal dominant disease: Mutation-independent allele-specific CRISPR editing

    Christie, K., Robertson, L., Conway, C., Blighe, K., Dedionisio, L., Chao-Shern, C., Kowalczyk, A., Marshall, J., Turnbull, D., Nesbit, M. A. & Moore, T. C. B., 5 Aug 2020, In : Molecular Therapy. 28, 8, p. 1846-1857 12 p.

    Research output: Contribution to journalArticle

  • Protein Analysis of the TGFBI R124H Mouse Model Gives Insight Into Phenotype Development of Granular Corneal Dystrophy

    Lukassen, M. V., Toftgaard Poulsen, E., Donaghy, J., Hage Mogensen, E., Christie, K. A., Roshanravan, H., DeDionisio, L., Nesbit, M. A., Moore, T. C. B. & Enghild, J. J., 18 Jun 2020, In : PROTEOMICS - Clinical Applications.

    Research output: Contribution to journalArticle

  • Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism

    Gaynor, K. U., Grigorieva, I. V., Mirczuk, S. M., Piret, S. E., Kooblall, K. G., Stevenson, M., Rizzoti, K., Bowl, M. R., Nesbit, M. A., Christie, P. T., Fraser, W. D., Hough, T., Whyte, M. P., Lovell-Badge, R. & Thakker, R. V., 29 Feb 2020, In : Endocrine Connections. 9, 2, p. 173-186 14 p.

    Research output: Contribution to journalArticle

    Open Access
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    Activities

    • 14 Participating in a conference, workshop, ...
    • 2 Invited talk

    ARVO Ethical Challenges and Solutions for CRISPR Treatment in Human

    Tara Moore (Speaker), & M. Andrew Nesbit (Speaker)

    2019 → …

    Activity: Talk or presentationInvited talk

    Mini symposium proposal, Emerging gene-driven therapies for anterior segment disease

    Tara Moore (Speaker), & M. Andrew Nesbit (Speaker)

    2019 → …

    Activity: Talk or presentationInvited talk

    ARVO

    Tara Moore (Participant), , Kathleen Christie (Participant), , Larry DeDionisio (Participant), , Connie Chao-Shern (Participant), , Kevin Blighe (Participant), & M. Andrew Nesbit (Participant)

    29 Apr 2018

    Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

    12th European Molecular Imaging Meeting

    Tara Moore (Participant), , Laura Mairs (Participant), , Diego Cobice (Participant), , Logan MacKay (Participant), , Kathleen Christie (Participant), & M. Andrew Nesbit (Participant)

    Apr 2017

    Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

    CiC Conference

    Tara Moore (Participant), , Paul Brennan (Participant), , D Finlay (Participant), , Mark Spence (Participant), , Agnes Awuah (Participant), , James McLaughlin (Participant), , Jonathan Moore (Participant), , M. Andrew Nesbit (Participant), , Emanuele Trucco (Participant), & Ruixuan Wang (Participant)

    Sep 2017 → …

    Activity: Participating in or organising an eventParticipating in a conference, workshop, ...