• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 2375 Citations
  • 25 h-Index
20002019
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Personal profile

Biography

Dr Andrew McDowell graduated from Queens University, Belfast (QUB) with a BSc (Hons) degree and PhD in Biochemistry. He then undertook post-doctoral studies in molecular medical microbiology within the School of Pharmacy and the School of Medicine, Dentistry and Biomedical Sciences at QUB (Centre of Infection & Immunity), as well as the Biological Research Centre of the Hungarian Academy of Sciences, Szeged (European Centre of Excellence).

He was appointed as a Lecturer in Stratified Medicine at Ulster University in 2013. Dr McDowell is also a Visiting Senior Research Fellow at the School of Pharmacy at QUB, and is a Fellow of the Higher Education Academy.

Dr McDowell has published widely and is an editor for the journals PLOSONE and BMC Microbiology (Clinical Microbiology and Vaccines section), and is on the advisory board of the post-publication peer review journal Sci. He has secured significant grant funding as PI, and has a wide network of collaborators at both the national and international level, and established links with industry.

Research Interests

Dr McDowell’s research focuses on the role of the human microbiota and microbiome in health and disease, an area now at the forefront of personalised medicine.

He has a particular interest in the role of infection in the development of cancer, and with support from Prostate Cancer UK he has established a programme of research into the role of the endogenous anaerobic bacterium Propionibacterium acnes in the development of prostate disease, with the goal of identifying new therapeutic pathways to reduce prostate cancer incidence in men. More recently, with funding from the British Skin Foundation, he has also been investigating the role of multi-antibiotic resistant strains of P. acnes in the development of ‘super-acne’, and investigating novel non-antibiotic approaches to treatment.

Dr McDowell also collaborates with other members of the Stratified Medicine team in relation to the role of the human microbiome in cardiovascular disease and mental health (depression). He has expertise in anaerobic bacteriology, biochemistry and molecular biology, including next generation sequencing, microbiomics, functional genomics, bioinformatics and phylogenetic analyses.

Teaching Interests

Dr McDowell teaches widely on the Stratified Medicine BSc and MSc degree programmes. He is module coordinator for the undergraduate module Genetic Inheritance and Omic Technologies (BIO124) and the postgraduate module Stratified Medicine and Healthcare Innovation (BIO832).

Oral conference and seminar presentations

Annual Microbiology Society Conference, Birmingham, UK (12th April, 2018). The potential role of the anaerobic bacterium Propionibacterium acnes in the aetiology of prostate cancer. 

Society for Anaerobic Microbiology, London. UK (2nd December 2013). Could Propionibacterium acnes infection of the prostate gland be an important, modifiable risk-factor for prostate cancer?

Stiefel (GlaxoSmithKline), North Carolina, USA (19th March 2013). Has population genetic analysis breathed new life into acne research?

David Geffen School of Medicine, UCLA, Los Angeles, USA (15th March 2013). Propionibacterium acnes as an underestimated cause of human disease.

University of Washington Medical Centre, Seattle, USA (13th March 2013). Laboratory Medicine Grand Rounds Lecture: Propionibacterium acnes as an underestimated cause of human disease.

Prostate Cancer UK, London (14th September, 2012). Understanding the role of bacteria in the aetiology of prostate cancer.

European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), London, (2nd April 2012). Symposium speaker: The Paradox of Propionibacterium acnes: benign commensal and virulent pathogen.

Administrative Roles

Dr McDowell also coordinates the marketing activities of Stratified Medicine and is a member of the School of Biomedical Sciences School Recruitment and Marketing Committee.

Fingerprint Dive into the research topics where Andrew Mc Dowell is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Propionibacterium acnes Medicine & Life Sciences
Acne Vulgaris Medicine & Life Sciences
Biofilms Medicine & Life Sciences
Skin Medicine & Life Sciences
Infection Medicine & Life Sciences
Multilocus Sequence Typing Medicine & Life Sciences
Bacteria Medicine & Life Sciences
Propionibacterium Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2000 2019

  • 2375 Citations
  • 25 h-Index
  • 52 Article
  • 17 Conference contribution
  • 3 Chapter
  • 1 Letter

A review of microscopy‑based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue

Capoor, M. N., Birkenmaier, C., Wang, J. C., Mc Dowell, A., Ahmed, F. S., Bruggemann, H., Coscia, E., Davies, D. G., Ohrt-Nissen, S., Raz, A., Ruzicka, F., Schmitz, J. E., Fischetti, V. A. & Slaby, O., 29 Jul 2019, In : European Spine Journal. p. 1-21 21 p.

Research output: Contribution to journalArticle

Open Access
File
Propionibacterium acnes
Biofilms
Microscopy
Acne Vulgaris
Sebaceous Glands
Open Access
File
Propionibacterium acnes
Acne Vulgaris
Population Genetics
Skin
Ribotyping
2 Citations (Scopus)
aprepitant
acne
Comb and Wattles
Acne Vulgaris
new combination

Clinical utility of CINtec® PLUS triage in equivocal cervical cytology and HPV primary screening

McDowell, A., McMenamin, M. & McKenna, M., 29 Aug 2018, In : American Journal of Clinical Pathology. 10 p.

Research output: Contribution to journalArticle

Triage
Cell Biology
Human papillomavirus 18
Colposcopy
Referral and Consultation

Draft Genome Sequence of Propionibacterium acnes subsp. elongatum Strain Asn12

Mc Dowell, A., Hunyadkürti, J., Magyari, M., Vörös, A., Horváth, B., Patrick, S. & Nagy, I., 19 Jul 2018, In : Microbiology Resource Announcements. 7, p. e00801-1 2 p.

Research output: Contribution to journalArticle

Open Access
File
Propionibacterium acnes
Genome
Anaerobic Bacteria
Opportunistic Infections
Acne Vulgaris

Thesis

Towards a personalised medicine strategy to reduce prostate cancer risk in men

Author: Yankova, E., May 2018

Supervisor: Mc Dowell, A. (Supervisor) & Gibson, D. (Supervisor)

Student thesis: Doctoral Thesis